England 12-6 Wales
A pair of first-half tries from Jonny May made it two Six Nations wins from two for England as they stretched their unbeaten home run to 15 games.
In wintry conditions at Twickenham May's predatory finishing combined with resolute defence and a canny kicking game held Wales at arm's length despite a tense finale.
Wales kept Eddie Jones' men scoreless in the second half as they clawed their way back into the game and Gareth Anscombe's late penalty put them within a converted try of the hosts, but handling errors and debatable decisions at key moments hurt their chances.
The visitors will also question the first-half decision by the television match official that denied Anscombe a try when he thought he had been the first player to get a hand to a chip into the England in-goal area.
England, who next face Scotland at Murrayfield, have now won 25 of their past 26 games and remain on target for a third championship title in three years.
Wales have won just one of their past six away matches in this tournament, the optimism engendered by their opening-day win disappearing against a white-shirted wall.